Miriam Linsenmeier is a postdoctoral researcher. She received her B.Sc. in Molecular Medicine from University of Ulm (Germany) in 2015, her M.Sc. in Biochemistry and Biophysics from University of Freiburg (Germany) in 2018 and her Ph.D. from ETH Zurich (Switzerland) in 2022. During her Ph.D., Miriam focused on understanding dynamic processes associated with the formation and maturation of biomolecular condensates using a variety of biophysical techniques. In 2022, Miriam earned a Swiss National Science Foundation (SNSF) post-doc fellowship. In 2022, Miriam also won a Milton Safenowitz Post-Doctoral Fellowship from the ALS Association! In 2024, Miriam won a Mildred Cohn Distinguished Postdoctoral Award and a Alzheimer's Association Research Fellowship! In 2025, Miriam was selected as a recipient of the ALS Scholars in Therapeutics Award from The Sean M. Healey & AMG Center for ALS, ALS Finding a Cure, & FightMND!

Publications

Barbieri, E.M., M. Linsenmeier, K.R. Whiteman, Y. Cheng, S. Braganza, K.E. Copley, P. Miranda-Castrodad, B. Lewis, K. Villafañe, D.A. Amado, B.L. Davidson, and J. Shorter. (2025). Scouring the human Hsp70 network uncovers diverse chaperone safeguards buffering TDP-43 toxicity. bioRxiv. doi: 10.1101/2025.05.10.653282. pdf file link

Copley, K.E., J.C. Mauna, H. Danielson, M. Ngo, L. Xie, A. Smirnov, M. Davis, L. Mayne, M. Linsenmeier, J.D. Rubien, B. Portz, B.L. Lee, H.M. Odeh, M. Hallegger, J. Ule, P. Pasinelli, Y. Poon, N.L. Fawzi, B.E. Black, C.J. Donnelly, B.K. Jensen, and J. Shorter. Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration. bioRxiv. doi: 10.1101/2024.12.14.628507. pdf file link

Cereghetti, G., V.M. Kissling, L.M. Koch, A. Arm, C.C. Schmidt, Y. Thüringer, N. Zamboni, P. Afanasyev, M. Linsenmeier, C. Eichmann, S. Kroschwald, J. Zhou, Y. Cao, D.M. Pfizenmaier, T. Wiegand, R. Cadalbert, G. Gupta, D. Boehringer, T.P.J. Knowles, R. Mezzenga, P. Arosio, R. Riek, and M. Peter. (2024). An evolutionarily conserved mechanism controls reversible amyloids of pyruvate kinase via pH-sensing regions. Dev. Cell. 59(14):1876-1891.e7. pdf file link

Khalil, B.*, M. Linsenmeier*, C.L. Smith, J.Shorter, and W. Rossoll. (2024). Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD. Mol. Neurodegen. 19(1):8. pdf file link (*Co-first author)

Linsenmeier, M., L. Faltova, C. Morelli, U. Capasso Palmiero, C. Seiffert, A. M. Küffner, D. Pinotsi, J. Zhou, R. Mezzenga, and P. Arosio. (2023). The interface of condensates of the hnRNPA1 low-complexity domain promotes formation of amyloid fibrils. Nat. Chem. 15(10):1340-1349. pdf file link

Linsenmeier, M., M. Hondele, F. Grigolato, E. Secchi, K. Weiss and P. Arosio. (2022). Dynamic arrest and aging of biomolecular condensates are modulated by low-complexity domains, RNA and biochemical activity. Nat. Comm. 13(1):3030. pdf file link

Capasso Palmiero, U., C. Paganini, M.R.G. Kopp, M. Linsenmeier, A.M. Küffner, P. Arosio. (2022). Programmable zwitterionic droplets as biomolecular sorters and model of membraneless organelles. Adv. Mat. 34 (4): 2104837. pdf file link

Küffner, A.M., M. Linsenmeier, F. Grigolato, M. Prodan, R. Zuccarini, U. Capasso Palmiero, L. Faltova, P. Arosio. (2021). Sequestration within biomolecular condensates inhibits Aβ42 amyloid formation. Chem. Sci. 12: 4373-4382. pdf file link

Linsenmeier, M., M.R.G. Kopp, S. Stavrakis, A. DeMello, P. Arosio. (2021). Analysis of membrane-less organelles and protein phase separation with microfluidic technology. Biochim. Biophys. Acta – Mol. Cell Res. 1868 (1): 118823. pdf file link

Malik, R., C. Corrales, M. Linsenmeier, H. Alalami, N. Sepanj, G. Bitan. (2020). Examination of SOD1 aggregation modulators and their effect on SOD1 enzymatic activity as a proxy for potential toxicity. FASEB J. 34 (9): 11957-11969. pdf file link

Kopp, M.R.G., M. Linsenmeier, B. Hettich, S. Prantl, S. Stavrakis, J.C. Leroux, P. Arosio. (2020). Microfluidic shrinking droplet concentrator for analyte detection and phase separation of protein solutions. Anal. Chem. 92 (8): 5803-5812. pdf file link

Linsenmeier, M., M.R.G. Kopp, F. Grigolato, L. Emmanouilidis, D. Liu, D. Zürcher, M. Hondele, K. Weis, U. Capasso Palmiero, P. Arosio. (2019). Dynamics of synthetic membraneless organelles in microfluidic droplets, Angew. Chem. Int. Ed. 58 (41): 14489-14494. pdf file link

Sachdev, R., M. Hondele, M. Linsenmeier, P. Valotton, C.F. Mugler, P. Arosio, K. Weis. (2019). Pat1 promotes processing body assembly by enhancing the phase separation of the DEAD-box ATPase Dhh1 and RNA. eLife. 8:e41415. pdf file link

Linsenmeier, M., and P. Arosio. (2018). Engineering aspects of protein interactions and self-assembly. Chimia. 72(5):304-308. pdf file link

Diederichs, S., L. Bartsch, J. C. Berkmann, K. Fröse, J. Heitmann, C. Hoppe, D. Iggena, D. Jazmati, P. Karschnia, M. Linsenmeier, T. Maulhardt, L. Möhrmann, J. Morstein, S.V. Paffenholz, P. Röpenack, T. Rückert, L. Sandig, M. Schell, A. Steinmann, G. Voss, J. Wasmuth, M.E. Weinberger, R. Wullenkord. (2016). The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations. EMBO Mol. Med. 8(5):442-457. pdf file link

Feneberg, E., P. Steinacker, S. Lehnert, A. Schneider, P. Walther, D. R. Thal, M. Linsenmeier, A.C. Ludolph, M. Otto. (2015). Limited role of free TDP-43 as a diagnostic tool in neurodegenerative diseases. Amyotroph. Lateral Scler. Front. Degener. 4 (5-6): 351-356. pdf file link